OSTHOLE AMELIORATES WEAR PARTICLE-INDUCED OSTEOGENIC IMPAIRMENT BY MITIGATING ENDOPLASMIC RETICULUM STRESS VIA PERK SIGNALING CASCADE

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade

Abstract Background Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty.Osteogenic impairment induced by wear particles is regarded as a crucial contributing factor in the development of osteolysis, with endoplasmic reticulum (ER) stress identified as a key underlying mecha

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Learning meaningful latent space representations for patient risk stratification: Model development and validation for dengue and other acute febrile illness

BackgroundIncreased data availability has prompted the creation of clinical decision support systems.These systems utilise clinical information to enhance health care provision, both to predict the likelihood of specific clinical outcomes or evaluate the risk of further complications.However, their adoption remains low due to concerns regarding the

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